1357 Johan I, King of Portugal (1383-1433) was born on April - 22.
1451 Isabella I, of Castile, Queen of Spain (1479-1504), patron of Columbus was born on April - 22.
1610 Alexander VIII, [Pietro Ottoboni], Italy, lawyer/Pope (1689-91) was born on April - 22.
1640 On this day in history birth of mariana Alcoforado, Portugal, nun
1658 On this day in history birth of giuseppe Torelli, Italy, composer (Concert Grossi op 8)
1682 On April - 22 birth of willem I Kerricx the Young, Flemish architect/sculptor/painter
1690 On this day in history birth of john Carteret, Earl Granville (C), English chief minister (1722-42)
1692 On April - 22 birth of james Stirling, Scottish mathematician (d. 1770)
0296 Death of Pope Caius on this day in history.
0536 On April - 22 agapitus I, Italian Pope (535-36), dies
1253 On this day in history elias van Cortona, Italian general (1232-39), dies at about 53
1355 On April - 22 eleonora Plantagenet, daughter of King Edward II, dies at 36
1462 Gilbert of Lannoy, master of Villerval/Tronchiennes/Santes, dies on April - 22.
1521 On April - 22 death of juan de Padilla, Spanish nobleman/communero-rebel, beheaded
1592 On April - 22 bartolommeo Ammanati, Italian sculptor/architect, dies at 80
1648 Catharina Belgian van Nassau, daughter of Willem, dies at 69 on April - 22.