Natural Disasters & Epidemics
Wednesday, 03 December 2025
0165 Antonine Plague in Roman Empire killing 5-10 million people 

0250 Plague of Cyprian in Europe killing 1 million+ (Unknown, but at least) people 

0412 (BC) epidemic in Greece (Northern Greece, Roman Republic) 

0429 (BC) Plague of Athens in Greece, Libya, Egypt, Ethiopia killing 75,000-100,000 people 

0526 antioch earthquake in Byzantine Empire (now Turkey) killing =300,000 people 

0541 Plague of Justinian in Europe and West Asia killing 25-100 million; 40-50% of population of Europe people 

0590 Pelagius II, Gothic Pope (579-90), dies from plague 

0664 plague of 664 in British Isles 

0735 Japanese smallpox epidemic in Japan killing 2 million (Approx. ?1/3 of entire Japanese population) people 

0746 plague of 746-747 in Byzantine Empire, West Asia, Africa 

1002 the Holy Roman Emperor Otto III dies of malaria January 23 at age 21 while conducting a campaign against the Romans 

1200 (BC) Influenza Epidemic in Babylon, or Babirus of the Persians, Central Asia, Mesopotamia and Southern Asia 

1270 Louis IX, the Saint, King of France (1226-70), dies from plague at 56 

1331 black Death in Europe, Asia and North Africa killing 75-200 million (10-60% of European population) people 

1345 saturn/Jupiter/Mars-conjunction; thought "cause of plague epidemic" 

1345 saturn/Jupiter/Mars-conjunction: thought "cause of plague epidemic" 

1348 italian poet Petrarch's beloved Laura dies of plague 

1348 Third wave of the Great plague hits the Old World 

1348 Petrarch's Laura, dies of plague 

1349 6,000 Jews, blamed for the Plague, are killed in Mainz 

1424 jan Zizka, Czech (army)leader (Hussieten), dies of plague at 46 

1485 sweating sickness (multiple outbreaks) in Britain (England) and later continental Europe killing 10,000+ people 

1510 influenza pandemic in Asia, North Africa, Europe killing Around 1% of those infected people 

1520 Smallpox Epidemic in Mexico killing 5-8 million (40% of population) people 

1545 cocoliztli Epidemic of 1545-1548 in Mexico killing 5-15 million (80% of population) people 

1556 Shaanxi earthquake in China killing 830,000 people 

1563 london plague in London killing 20,100+ in London people 

1570 A tidal wave in the North Sea devastates the coast from Holland to Jutland, killing more than 1,000 people 

1576 Titian, [Tiziano Vecelli], Italian painter, dies of plague 

1576 cocoliztli epidemic of 1576 in Mexico killing 2-2.5 million (50% of population) people 

1592 measles in Seneca nation 

1592 malta plague epidemic in Malta killing 3,000 people 

1592 london plague in London killing 19,900+ in London and outer parishes people 

1596 Plague in Spain 

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